Our evidence

In almost 20 years of activity, TIGEM AAV Vector Core has collaborated with leading gene therapy scientists and produced more than 3000 AAV lots. Its contribution has been recognized in 75 peer-reviewed scientific publications.

Publications related to AAV Vector Core scientific knowledge that are at the basis of InnovaVector’s  expertise

  • A. M. Maguire, F. Simonelli, E. A. Pierce, E. N. Jr Pugh, F. Mingozzi, J. Bennicelli, S. Banfi, K. A. Marshall , F. Testa , E. M. Surace, S. Rossi, A. Lyubarsky, V.R. Arruda, B. Konkle, E. Stone, J. Sun, J. Jacobs, L. Dell’Osso, R. Hertle, J. X. Ma, T. M. Redmond, X. Zhu, B. Hauck, O. Zelenaia, K. S. Shindler, M. G. Maguire, J. F. Wright, N. J. Volpe, J. W. McDonnell, A. Auricchio, K.A. High, J. Bennett (2008) Safety and Efficacy of Gene Transfer for Leber’s Congenital Amaurosis. N Engl J Med. 358(21):2240-8.
  • Lock, M., McGorray, S., Auricchio, A., Ayuso, E., Beecham, E. J., Blouin-Tavel, V., Bosch, F., Bose, M., Byrne, B. J., Caton, T., Chiorini, J. A., Chtarto, A., Clark, K. R., Conlon, T., Darmon, C., Doria, M., Douar, A., Flotte, T. R., Francis, J. D., Francois, A., … Snyder, R. O. (2010). Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material. Human gene therapy, 21(10), 1273–1285.
  • Doria M, Ferrara A, Auricchio A. AAV2/8 vectors purified from culture medium with a simple and rapid protocol transduce murine liver, muscle, and retina efficiently. Hum Gene Ther Methods. 2013 Dec 1; 24(6):392-8. doi: 10.1089/hgtb.2013.155. Epub 2013 Sep 12.
  • Trapani I, Colella P, Sommella A, Iodice C, Cesi G, de Simone S, Marrocco E, Rossi S, Giunti M, Palfi A, Farrar GJ, Polishchuk R, Auricchio A (2014). Effective delivery of large genes to the retina by dual AAV vectors. EMBO Mol Med 6 (2):194-211.
  • Ayuso E, Blouin V, Lock M, McGorray S, Leon X, Alvira MR, Auricchio A, Bucher S, Chtarto A, Clark KR, Darmon C, Doria M, Fountain W, Gao G, Gao K, Giacca M, Kleinschmidt J, Leuchs B, Melas C, Mizukami H, Muller M, Noordman Y, Bockstael O, Ozawa K, Pythoud C, Sumaroka M, Surosky R, Tenenbaum L, Van der Linden I, Weins B, Wright JF, Zhang X, Zentilin L, Bosch F, Snyder RO, Moullier P. Manufacturing and Characterization of a Recombinant Adeno-Associated Virus Type 8 Reference Standard Material. Hum Gene Ther. 2014 Oct 2.
  • Ferla R, Alliegro M, Marteau JB, Dell'Anno M, Nusco E, Pouillot S, Galimberti S, Valsecchi MG, Zuliani V, Auricchio A (2017). Non-clinical Safety and Efficacy of an AAV2/8 Vector Administered Intravenously for Treatment of Mucopolysaccharidosis Type VI. Mol Ther Methods Clin Dev 6 143-158.